课题:
1、上海市2021年度“科技创新行动计划”生物医药科技支撑专项,21S11902000,新型靶向STAT3-SH2的双磷酸化抑制剂WB737抗胰腺癌功能与机理研究,2021.08-2024.07,20万元、在研、主持。
2、国家自然科学基金面上项目,81872418、新型小分子化合物ZY-444靶向丙酮酸羧化酶抑制乳腺癌生长和转移的机理研究和转移的机理研究、2019.01-2022.12、57万元、在研、主持。
3、国家自然科学基金青年项目,81202104、乳腺基质细胞和导管上皮细胞中的P450酶在乳腺化学致癌中的作用、2013/01-2015/12、23万元、结题、主持。
4、中国博士后科学基金(第61批面上资助一等),2017M610278、具核梭杆菌致大肠癌级联激发及其分子免疫机制研究、2017-2018、8万元、结题、主持。
5、上海市自然科学基金,18ZR1431700、方格星虫来源的血管紧张素转化酶(ACE)抑制肽抗高血压的功能机制、构效分析和活性优化研究、2018.06-2021.05、20万元、在研、主持。
6、上海市卫生计生系统优秀青年医学人才培养计划,2017YQ048、靶向微管蛋白的抗肿瘤小分子的合理设计及作用机理研究、2017/07-2020/06、61万元、结题、主持。
7、上海市卫生和计划生育委员会重点项目,201540027、新型Hedgehog信号通路抑制剂抗胰腺癌生长的作用与机制、2015/08-2017/7、15万元、结题、主持。
8、上海市奉贤区科委重点项目,20141001、方格星虫血管紧张素转化酶抑制肽抗高血压机制研究、2014/07-2017/06、11万元、结题、主持。
SCI论文:
1. Jiannan Zhao, Yongling Li, Jing Ma, Jingting Liu, Ruoxuan Xiao, Linlin Wang, Peng Li, Yinyan He, Feng Qian, Ao Zhang, Zhen-Liang Sun, Chunyong Ding.
Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes. European Journal of Medicinal Chemistry. (2022, IF= 6.514)
2. Huang Chen, Ying Miao, Aiwu Bian, Jiangnan Ye, Jing Wang, Xiaonan Cong,Shuyi Jian, Zhengfang Yi, Lin Liang, Zhenliang Sun d, Fan Yang, Tao Ding. A novel small-molecule activator of unfolded protein response suppresses castration-resistant prostate cancer growth. Cancer Letters.(2022, IF= 8.679)
3. Guan-Jun Wang, Shu-Yu Zhang, Zhen-Liang Sun, Peng Li, and Tong-Mei Ding. Highly Site- and Enantioselective N—H Functionalization of N-Monosubstituted Aniline Derivatives Affording Pyrazolones Bearing a Quaternary Stereocenter. Chinese Journal of Chemistry. (2022, IF= 6.0)
4. Yajing Xing, Weikai Guo, Min Wu, Jiuqing Xie, Dongxia Huang, Pan Hu,Miaoran Zhou, Lin Zhang, Qiansen Zhang, Peili Wang, Xin Wang, Guixue Wang,Huangan Wu, Cili Zhou, Yihua Chen, Mingyao Liu, Zhengfang Yi, Zhenliang Sun. An orally available small molecule BCL6 inhibitor effectively suppressesdiffuse large B cell lymphoma cells growth in vitro and in vivo. Cancer Letters.(2022, IF= 8.679)
5. Jing Gao, Yuanjin Zhang, Xueqin Lei, Yuan Xu, Zhenliang Sun, Xin Wang. Risk assessment of the inhibition of hydroxygenkwanin on human and rat cytochrome P450 by cocktail method. Toxicology in Vitro. (2021, IF=3.5)
6. Shihong Peng, Pan Hu, Yu-Tian Xiao, Weiqiang Lu, Dandan Guo, Shixiu Hu,Jiayi Xie, Minna Wang, Weiwei Yu, Junjie Yang, Huang Chen, Xiaomin Zhang, Yasheng Zhu, Ye Wang8, Yue Yang, Guanghui Zhu, Sujun Chen, Jian Wang, Bo Zhang, Weidong Chen, Huangan Wu, Zhenliang Sun, Tao Ding, Hankun Zhang, Zhengfang Yi, Mingyao Liu, Shancheng Ren.
Single-cell analysis reveals EP4 as a target for restoring T cell infiltration and sensitizing prostate cancer to immunotherapy. Clinical Cancer Research. (2021, IF=12.531)
7. Yuan He,Weiqiong Kan,Yunqi Li,Yun Hao,Anling Huang, Haijun Gu, MinnaWang,Qingqing Wang,Jinlian Chen,Zhenliang Sun,Mingyao Liu,Yihua Chen,Zhengfang Yi. A potent and selective small molecule inhibitor of myoferlin attenuates colorectal cancer progression. Clinical and Translational Medicine. (2021,IF=7.919)
8. JuanJuan Feng, Wenhao Jiang, Yanan Liu, Wanfeng Huang, Kewen Hu, Kun Li,Jing Chen, Chengbin Ma, Zhenliang Sun, Xiufeng Pang. Blocking STAT3 by pyrvinium pamoate causes metabolic lethality in KRAS-mutant lung cancer. Biochemical Pharmacology. (2019, IF=4.825)
9. Qingxiang Lin, Yuan He, Xue Wang, Yong Zhang, Meichun Hu, Weikai Guo, Yundong He, Tao Zhang, Li Lai, Zhenliang Sun, Zhengfang Yi,* Mingyao Liu,* and Yihua Chen*. Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. Advanced Science. (2019, IF=15.804)
10. Ting Shao, Tingting Fan, Wenshu Tang, Yanting Sun, Song Gao, Huang Chen, Zhenliang Sun*, Mingyao Liu* and Zhengfang Yi*. Ethyl-N-dodecanoyl-l-arginate hydrochloride combats pathogens with low-resistance generationby membrane attack and modifies gut microbiota structure. microbial biotechnology. (2019, IF=4.857)
授权国家发明专利:
1、 2021 一种具有1,3-二氧戊烷连接单元的乌药烷倍半萜二聚体及其制备方法和用途 201811494785.7
2、 2021 2-氨基萘满衍生物的制备方法及其中间体 201811508275.0
3、 2021 一种青葙杂萜化合物、其制备方法及其应用 201810750923.7
4、 2019 GSK961081及其中间体的合成方法 201611161559.8
5、 2018 一种查尔酮类衍生物、制备方法、药物组合物及应用 201610586492.6
6、 2018 齐墩果烷型三萜皂苷类化合物、其制备方法及其应用 2015110209944
7、 2018 一种血管紧张素转化酶抑制肽及其制备方法 2015102173669
8、 2018 一种青葙素、其制备方法及其应用 2015109772280
9、 2016 一种齐墩果烷皂苷类化合物及用途 201110225717.2
10、 2014 一种丹参酮衍生物及其制备方法和应用201310245320.9