孙振亮

导师资格:博士研究生导师

学科专业:药学、免疫学

联系方式:zhenliang6@126.com

现任职务: 上海交通大学附属第六人民医院南院(奉贤医院)副院长、 上海市皮肤医学重点学科负责人、 皮肤健康与疾病研究院院长

一、个 人 简 介

博士研究生导师,临床医学(普外科)博士后,博士研究生,研究员,教授。主持国家自然科学基金、市自然基金、卫生健康委行业专项课题10项。发表学术论文(SCI收录)100篇,授权国家发明专利15项。荣获上海市优秀发明选拔赛职工技术创新成果金奖、上海市中西医结合科学技术奖三等奖等。

二、荣誉

上海市东方英才计划

上海市卫生系统青年人才奖励基金会首届恒杰-专项技术扶植计划

事业单位工作人员记功

上海市奉贤区人力资源与社会保障局嘉奖

上海市人才发展资金资助计划

上海市卫生健康行业青年五四奖章

“滨海贤人”系列优秀人才-拔尖人才

上海市卫生计生系统优秀青年医学人才培养计划

上海市医务青年管理十杰提名奖

上海市青年岗位能手

上海市卫生系统第十四届“银蛇奖”提名奖

三、主 要 学 习 与 工 作 经 历

上海医药工业研究院

中国人民解放军第二军医大学

上海交通大学附属第六人民医院南院

同济大学附属第十人民医院临床医学博士后

国家卫生健康委挂职学习

四、主 要 科 研 工 作 与 成 绩

(1)课题:

1、上海市2021年度“科技创新行动计划”生物医药科技支撑专项,21S11902000,新型靶向STAT3-SH2的双磷酸化抑制剂WB737抗胰腺癌功能与机理研究。

2、国家自然科学基金面上项目,81872418、新型小分子化合物ZY-444靶向丙酮酸羧化酶抑制乳腺癌生长和转移的机理研究和转移的机理研究。

3、国家自然科学基金青年项目,81202104、乳腺基质细胞和导管上皮细胞中的P450酶在乳腺化学致癌中的作用。

4、中国博士后科学基金(面上资助一等),2017M610278、具核梭杆菌致大肠癌级联激发及其分子免疫机制研究。

5、上海市自然科学基金,18ZR1431700、方格星虫来源的血管紧张素转化酶(ACE)抑制肽抗高血压的功能机制、构效分析和活性优化研究。

6、上海市卫生计生系统优秀青年医学人才培养计划,靶向微管蛋白的抗肿瘤小分子的合理设计及作用机理研究。

7、上海市卫生和计划生育委员会重点项目,新型Hedgehog信号通路抑制剂抗胰腺癌生长的作用与机制。

(2)SCI论文:

  1. Yao Feng, Yu Zhang, Kai Huang, Sen Li, Hongwei Cao, Pengxiao Zhang, Man Wang, Zhenliang Sun*, Xiao Guan. Rice bran protein ffbril and chitin nanoffber complexes as a new material for fat substitution and saltiness enhancement. Food Chemistry.
  2. Haiying Zhu& Zhenliang Sun. Optimizing interprofessional collaboration: Enhancing nurse -physician trainee dynamics. Medical Teacher. 
  3. Qiqi Sun,Zhenfeng Yu,Lei Luo Sen,LiXiao Guan,Zhenliang Sun. Modulation of Inflammation Levels and the Gut Microbiota in Mice with DSS-Induced Colitis by a Balanced Vegetable Protein Diet.
  4. Kun Zhao,Zhenliang Sun. Letter to the Editor-Dairy consumption and risk of prediabetes and type 2 diabetes in the Fenland study. Clinical Nutrition.
  5. Mengfei Xue, Ruijie Yang, Guihong Li, Zhizhan Ni, Yuqing Chao, Kairui Shen, Hua Ren, Bing Du, Juliang Qin, Zhenliang Sun. LGR4 Deficiency Aggravates Skin Inflammation and Epidermal Hyperplasia in Imiquimod-Induced Psoriasis.IMMUNOLOGY.
  6. Haoming Wu, Man Wang, Xiaolong Ren, Zhipeng Li, Lianzhong Ai,Fan Xie,Zhenliang Sun. Preparation of type 3 rice resistant starch using high-pressure homogenous coenzyme treatment and investigating its potential therapeutic effects on blood glucose and intestinal flora in db/db mice. International Journal of Biological Macromolecules.
  7. Zhang,Fang Zhu, Yiyun Cheng, Zhenliang Sun, Dianwen Song. A targeted and core-shell structured gambogic acid nanomedicine for ameliorating breast cancer-associated osteolysis. Nano Today.
  8. Fang Zhu, Zhenliang Sun,Yiwen Li, Chao Chen, Yiyun Cheng. Polycatechols: Promising materials for biomedical applications. Progress in Polymer Science.
  9. Kun Zhao & Zhenliang Sun. Continuing education and professional development: teachers’ roles and challenges in CBME implementation. Medical Teacher.
  10. Gui-Hong Li, Ying Miao, Huang Chen, Meng-Fei Xue, Jia-Yu Wang, Jing-Wen Zhang, Zheng-Fang Yi, Zhen-Liang Sun. The small-molecule drug homoharringtoninetargets HSF1 to suppress pancreatic cancer progression. American Journal Of Cancer Research.  
  11. Jing Liu, Pu Chen, Hongdong Song, Pengxiao Zhang, Man Wang, Zhenliang Sun, and Xiao Guan. Prediction of Cholecystokinin-Secretory Peptides Using Bidirectional Long Short-term Memory Model Based on Transfer Learning and Hierarchical Attention Network Mechanism.Biomolecules.
  12. JIAHUI LI, BIN TANG, YING MIAO, GUIHONG LI and ZHENLIANG SUN.Targeting of STAT5 using the small molecule topotecan hydrochloride suppresses acute myeloid leukemia progression. Oncology reports.
  13. Zhiqin Fang, Hongyin Sun, Yutong Wang, Zhenliang Sun, Mingzhu Yin. Discovery of WD-890: A novel allosteric TYK2 inhibitor for the treatment of multiple autoimmune diseases. Biomedicine & Pharmacotherapy.
  14. Meng-Ting Han, Hua Pei, Qi-Qi Sun, Cheng-Long Wang, Peng Li, Ya-Ya Xie, Li-Jun Cao, Xing-Xing Zhang, Zhen-Liang Sun. ZY-444 inhibits the growth and metastasis of prostate cancer by targeting TNFAIP3 through TNF signaling pathway.American Journal of Cancer Research.
  15. Dandan Yang, Mengli Fu, Qi Zhao, Yong Wang, Tan Li, Bei Feng, Echuan Li, Yoshihito Nishijima, Zhenliang Sun, Zhenlin Hu. α-ionone promotes keratinocyte functions and accelerates epidermal barrier recovery. Annals of Translational Medicine.
  16. Cheng-LongWang, Yong-Ling Li, Le Wang, Xun-Hui Wang, Jia Zhou, He-Yuan Bai, Tong-Mei Ding, Zhen-Liang Sun. Direct Organocatalytic Asymmetric para C–H Aminoalkylation of Aniline Derivatives Affording Diarylmethylamines. SYNTHESIS
  17. Ji’an Xia, Yu Zhang, Kai Huang, Hongwei Cao, Qiqi Sun, Man Wang, Suhua Zhang, Zhenjiang Sun, Xiao Guan. Different multi-scale structural features of oat resistant starch prepared by ultrasound combined enzymatic hydrolysis affect its digestive properties. Ultrasonics Sonochemistry.
  18. Hongdong Song, Qingyu Wang, Zhuwei Shao, Xinyue Wang, Hongwei Cao, Kai Huang, Qiqi Sun, Zhenliang Sun and Xiao Guan.In vitro gastrointestinal digestion of buckwheat (Fagopyrum esculentum Moench) protein: release and structural characteristics of novel bioactive peptides stimulating gut cholecystokinin secretion. Food &Function
  19. Ranqing Li, Hongwei Cao, Yueqing Wang, Hongdong Song, Kai Huang, Yu Zhang, Qiqi Sun, Zhenliang Sun, Xiao Guan. Improving physicochemical stability of highland barley-based milk by the addition of endogenous β-glucan. Food Hydrocolloids.
  20. Yu Zhang, Ruojie Hao, Junda Chen, Sen Li, Kai Huang, Hongwei Cao,Mohamed A. Farag, Maurizio Battino, Maria Daglia, Esra Capanoglu, Fan Zhang, Qiqi Sun, Jianbo Xiao, Zhenliang Sun & Xiao Guan. Health benefits of saponins and its mechanisms: perspectives from absorption, metabolism, and interaction with gut. Critical Reviews in Food Science and Nutrition.
  21. Juanjuan Feng, Zhengke Lian, Xinting Xiaa, Yue Lua,Kewen Hu, Yunpeng Zhang, Yanan Liu, Longmiao Hua, Kun Yuan, Zhenliang Sun, Xiufeng Pang.Targeting metabolic vulnerability in mitochondria conquers MEK inhibitor resistance in KRAS-mutant lung cancer. Acta Pharmaceutica Sinica B.
  22. Yuanjin Zhang,Jing Gao, Yuan Xu, Jie Liu, Shengbo Huang, Guihong Li, Bingyi Yao, Zhenliang Sun, Xin Wang. Investigation of cytochrome P450 inhibitory properties of deoxyshikonin, a bioactive compound from Lithospermum erythrorhizon Sieb. et Zucc. Phytotherapy Research.
  23. Jiannan Zhao, Yongling Li, Jing Ma, Jingting Liu, Ruoxuan Xiao, Linlin Wang, Peng Li, Yinyan He, Feng Qian, Ao Zhang, Zhen-Liang Sun, Chunyong Ding.

Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes. European Journal of Medicinal Chemistry.

  1. Huang Chen, Ying Miao, Aiwu Bian, Jiangnan Ye, Jing Wang, Xiaonan Cong,Shuyi Jian, Zhengfang Yi, Lin Liang, Zhenliang Sun d, Fan Yang, Tao Ding.A novel small-molecule activator of unfolded protein response suppresses castration-resistant prostate cancer growth. Cancer Letters.
  2. Guan-Jun Wang, Shu-Yu Zhang, Zhen-Liang Sun, Peng Li, and Tong-Mei Ding. Highly Site- and Enantioselective N—H Functionalization of N-Monosubstituted Aniline Derivatives Affording Pyrazolones Bearing a Quaternary Stereocenter. Chinese Journal of Chemistry.
  3. Yajing Xing, Weikai Guo, Min Wu, Jiuqing Xie, Dongxia Huang, Pan Hu,Miaoran Zhou, Lin Zhang, Qiansen Zhang, Peili Wang, Xin Wang, Guixue Wang,Huangan Wu, Cili Zhou, Yihua Chen, Mingyao Liu, Zhengfang Yi, Zhenliang Sun.An orally available small molecule BCL6 inhibitor effectively suppressesdiffuse large B cell lymphoma cells growth in vitro and in vivo. Cancer Letters.
  4. Jing Gao, Yuanjin Zhang, Xueqin Lei, Yuan Xu, Zhenliang Sun, Xin Wang.Risk assessment of the inhibition of hydroxygenkwanin on human and rat cytochrome P450 by cocktail method. Toxicology in Vitro.
  5. Shihong Peng, Pan Hu, Yu-Tian Xiao, Weiqiang Lu, Dandan Guo, Shixiu Hu,Jiayi Xie, Minna Wang, Weiwei Yu, Junjie Yang, Huang Chen, Xiaomin Zhang, Yasheng Zhu, Ye Wang8, Yue Yang, Guanghui Zhu, Sujun Chen, Jian Wang, Bo Zhang, Weidong Chen, Huangan Wu, Zhenliang Sun, Tao Ding, Hankun Zhang, Zhengfang Yi, Mingyao Liu, Shancheng Ren.

Single-cell analysis reveals EP4 as a target for restoring T cell infiltration and sensitizing prostate cancer to immunotherapy. Clinical Cancer Research.   

  1. Duo Cao, Peng Sun, Sumana Bhowmick, Yahui Wei, Bin Guo, Yanhong Wei, Luis A.J. Mur e, Zhenliang Sun.Secondary metabolites of endophytic fungi isolated from Huperzia serrata. Fitoterapia.
  2. Song-Song Wen, Yan Wang, Jia-Ping Xu, Qi Liu, Lei Zhang, Jing Zheng, Lin Li, Na Zhang, Xin Liu, Yu-Wen Xu & Zhen-Liang Sun. Two new sesquiterpenoid lactone derivatives fromLindera aggregata. Natural Product Research.
  3. Yuan He,Weiqiong Kan,Yunqi Li,Yun Hao,Anling Huang, Haijun Gu, MinnaWang,Qingqing Wang,Jinlian Chen,Zhenliang Sun,Mingyao Liu,Yihua Chen,Zhengfang Yi. A potent and selective small molecule inhibitor of myoferlin attenuates colorectal cancer progression. Clinical and Translational Medicine.
  4. JuanJuan Feng, Wenhao Jiang, Yanan Liu, Wanfeng Huang, Kewen Hu, Kun Li,Jing Chen, Chengbin Ma, Zhenliang Sun, Xiufeng Pang. Blocking STAT3 by pyrvinium pamoate causes metabolic lethality in KRAS-mutantlung cancer. Biochemical Pharmacology.
  5. Han Luo, Yuan Xua, Dongyi Sun, Yi Cheng, Zhenliang Sun∗, Jing Gao,Yuanjin Zhang,  Xin Wang.∗ Assessment of the inhibition risk of paris saponins, bioactive compounds from Paris polyphylla, on CYP and UGT enzymes via cocktail inhibition assays. Regulatory Toxicology and Pharmacology.
  6. Qingxiang Lin, Yuan He, Xue Wang, Yong Zhang, Meichun Hu, Weikai Guo, Yundong He, Tao Zhang, Li Lai, Zhenliang Sun, Zhengfang Yi,* Mingyao Liu,* and Yihua Chen*. Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. Advanced Science.

Ting Shao, Tingting Fan, Wenshu Tang, Yanting Sun, Song Gao, Huang Chen, Zhenliang Sun*, Mingyao Liu* and Zhengfang Yi*. Ethyl-N-dodecanoyl-l-arginate hydrochloride combats pathogens with low-resistance generationby membrane attack and modifies gut microbiota structure. microbial biotechnology.

(3)授权国家发明专利:

一种丹参酮衍生物及其制备方法和应用    2013 1 0245320.9

一种齐墩果烷皂苷类化合物及用途    2011 1 0225717.2

一种青葙素、其制备方法及其应用    2015109772280

一种血管紧张素转化酶抑制肽及其制备方法    2015102173669

齐墩果烷型三萜皂苷类化合物、其制备方法及其应用    2015110209944

一种查尔酮类衍生物、制备方法、药物组合物及应用    201610586492.6

GSK961081及其中间体的合成方法    201611161559.8

一种青葙杂萜化合物、其制备方法及其应用    201810750923.7

一种具有1,3-二氧戊烷连接单元的乌药烷倍半萜二聚体及其制备方法和用途    201811494785.7

一种黄酮并单萜类化合物及其制备方法和应用 201910624919.0

2-氨基萘满衍生物的制备方法及其中间体       201811508275.0

一种乌药烷型倍半萜二聚体及其制备方法和用途    201811494784.2 

一种齐墩果烷型三萜皂苷化合物及其制备方法和应用     202211347769.1

四、主 要 科 研 工 作 与 成 绩

上海市药理学会第一届药物临床试验专业委员会委员

上海市药学会天然药物化学专业委员会常务委员

全国卫生产业企业管理协会精准医疗分会委员

上海市植物学会药物植物与植物药专业委员会委员

中国医药教育协会皮肤药学专业委员会委员

中国医药质量管理协会临床研究质量与评价专业委员会委员

上海市医学伦理学会第八届理事

中国医药教育协会皮肤药学专业委员会委员

中国药学会药物临床评价研究专业委员会第四届委员会青年委员

五、主 要 研 究 方 向

1、生物活性天然产物的合成与功能研究

2、免疫药理学

3、临床药学

4、工业药学

六、全日制专业学位联合培养单位

上海交通大学

华东师范大学

南方医科大学

安徽理工大学

上海理工大学

上海中医药大学

锦州医科大学

上海健康医学院